The Lipoprotein Analysis Laboratory, located at Wake Forest Innovation Quarter, has developed diets capable of inducing desired levels of hyperlipoproteinemia using various preclinical platforms.
The characterization of plasma lipoprotein distributions by size and composition, as well as distribution among major classes by cholesterol and triglyceride, are endpoints that are frequently used to define high-risk situations for cardiovascular disease, and we provide the possibility to include several assessments of these endpoints.
We have had experience with lipid and lipoprotein analyses in various animal models including mice, rabbits, pigs and monkeys, and can provide analyses in human samples as well. We have analyzed the effects of different dietary manipulations and can provide suggestions about experimental design when such variables are to be considered.
Not only do we provide analyses of plasma lipoproteins, but we also provide analyses of tissue lipid concentrations, as pertinent to atherosclerosis evaluations, for example.
We typically work with no more than 100 samples for comparison among various endpoints.